More than 100 million people in the United States have received one of the coronavirus vaccines authorized by the US Food and Drug Administration to receive more than 200 million vaccines from President Biden during his first 100 days in office.
But some people did not come to the second shot of messenger-RNA vaccines, which require two doses to achieve the strongest և longest immunity.
Leading National Infectious Diseases Specialist Anthony Fauci recently expressed concern that while one dose has been shown to be as effective as 80 percent, it is “to some extent 80 percent.”
It is not yet known how many antibodies per dose will be given, as this data was not included in the Pfizer և Moderna clinical trials. But health experts say it is clear that people who get one stroke and stop there will not get the full protective benefits of the vaccine.
“You are in a tense zone if you do not have full influence,” Fauci told reporters.
What are the possible consequences of skipping a second dose?
Federal and local health officials say few people have been able to obtain the second dose of Pfizer և Moderna vaccines, which were approved for emergency use last year. Johnson & Johnson vaccine requires only one dose. However, federal health officials have called for a halt to the vaccine during a rare blood tissue probe that resulted in 1 to 1 percent of the 1.1 million vaccines.
A recent study by the Centers for Disease Control and Prevention found that the vast majority of people who started a series of mRNA vaccines in the first few months of a coronavirus vaccination program completed it. However, about 3% of them did not.
Kristen Marx, an infectious disease specialist at Weill Cornell Medicine և New York-Presbyterian, said that if people start giving up the second dose, she believes “you will start to see more infections.”
“People who have been vaccinated, who have seen most of the cases of crocodiles who have been taken to hospital, have had people who have not yet received a second dose. “I think that tells us something,” he said.
MRNA vaccines were designed to be given as a two-dose series based on clinical trial data showing that two doses of Pfizer և Moderna vaccines were needed for maximum efficacy of approximately 95%. In the real world, vaccines are 80% more effective at preventing infection between two doses in a series, according to a recent CDC study. But health experts say the antibodies may never reach the level of protection they need, and will likely weaken without a second shot.
In addition to the effectiveness and longevity of the vaccine, John on Moore, a professor of microbiology and immunology at Weill Cornell Medicine, said there was a problem with virus variants. Based on laboratory studies, he explained, the researchers believe that some of the variants that are beginning to circulate are capable of “actually coming out of the level of the first antibody produced by the first dose.”
The second dose is what “boosts your antibodies,” providing protective immunity, he said.
Are there situations where I need to do this?
Although rare, the CDC says that anyone who has a severe allergic reaction to anaphylaxis after the first dose, or even an immediate allergic reaction that does not require urgent treatment, should not take a second dose of any of the mRNA vaccines.
But “just having a fever or body aches is not a reason not to take a second dose,” Marx said.
There is some debate as to whether people who have had COVID-19 may be in a different category.
The CDC still recommends that people complete the range of vaccines, regardless of whether they have had COVID-19, as there are too many unknowns about how well they are protected. But there are some early studies that suggest that some people with the virus get a stronger immune response than one dose of the vaccine than those who have never.
Moore, at Weill Cornell Medicine, said there was growing evidence that “one dose is enough to boost immunity, the second dose does not increase much” in some people with the virus. But researchers say the strength of the response to these antibodies needs further study.
It may also be recalled that the immune response to COVID-19 varies from person to person, says Rob Murphy, executive director of the Institute for Global Health and Professor of Medicine and Biomedical Engineering at Northwestern University. He said that the level of natural antibodies in a person suffering from the virus depends on whether the person had a mild case or a “clinically relevant” egg.
“You just can’t predict the immunological response you get from having a coccyx. “Some people will probably not need the vaccine at all, but we do not have the markers to confirm that,” he said.
So at least the CDC has not changed its recommendations.
What should I do if I miss a second dose?
Experts agree. Go and get it now.
Technically, the second dose should be administered 21 days after the first dose of Pfizer 28 28 days for Moderna. However, the CDC says that in cases where a second dose cannot be given within that period, it can be given up to six weeks after the first dose.
Even so, owning one is still beyond the reach of the average person, regardless of how long it takes.
It is not recommended to start the vaccine again.
Moore said there is simply too much evidence to ignore that a second dose is helpful.
“You have the right to do that. “Go and get it, that’s the message,” he said.