These scientists thought that endocannabinoids were intoxicants. Studies show that cannabis is chemically similar to cannabis, and our body-made cannabinoids are abundant during pleasurable activities, such as orgasms and running. They can cross the blood-brain barrier, making them a viable candidate for any high-level runner.
Several previous attempts have reinforced this possibility. In a remarkable 2012 study, researchers used dogs to swallow dogs, people, and fetuses to run on tracks by measuring the levels of endocannabinoids in their blood. Dogs և humans are superficial, that is, they have bones: muscles at a well-adjusted running distance. Ferrets are not; they bend, run, but rarely go miles; they do not produce extra cannabinoids when running on a treadmill. However, the dogs և people did it, noting that they probably had a high level of running, և can be found in their internal cannabinoids.
That study did not rule out the role of endorphins, however, as Dr. Johannes Fuss realized. The director of the Human Behavior Laboratory at the Medical Center of the University of Hamburg-Eppendorf in Germany, his colleagues have long been interested in how different actions affect the internal workings of the brain, the study of the helmet, after reading others thought that it is possible to look more closely :
They started with mice who are impatient runners. In a 2015 study, they chemically blocked endorphins in the brains of animals, allowed them to run, and then did the same thing by taking endocannabinoids. When their endocannabinoid system was shut down, the animals finished the run as restless and compressed as at the beginning, suggesting that they did not have a high level of runner. But when their endorphins were blocked, their behavior was calmer and relatively happier after running. They seem to have developed that familiar, soft buzz, even though their endorphin systems were inactive.
Mice are not strictly human. So for a new study published in the journal Psychoneuroendocrinology in February, Dr. Fuss և and his colleagues set out to replicate the experience on humans as much as possible. Recruiting 63 experienced female runners, they invited them to a lab, tested their fitness, current emotional state, took blood, and randomly prescribed naloxone, a drug that blocks opioid intake, and the rest as a placebo. (The drug they used to block endocannabinoids in mice was not legal in humans, so they could not repeat that part of the experiment.)