An unusual study, in which thousands of heart patients were reported to be following their online health status after taking low- or regular-strength aspirin, found that both doses seemed equally safe and effective in preventing additional heart problems and strokes. for:
But there is a big caveat. People had such a high preference for low-dose that it was unclear whether the results could confirm that the treatment was really adequate, say some independent experts. Half of those who were told they should take a higher dose took the lower dose or stopped taking aspirin altogether.
“Patients mostly decided for themselves what they wanted to take because they bought the aspirin on their own,” said Dr. Salim Virani, a cardiologist at Baylor College of Medicine in Houston, who had no role in the study.
“Still, the results show that there is very little reason to take a larger dose of 325 milligrams, which many doctors say will work better than 81 milligrams of ‘baby aspirin,'” he said.
The results were published Saturday in the New England Journal of Medicine and discussed at the American College of Cardiology conference.
Aspirin helps prevent blood clots, but it is not recommended for healthy people who have not yet had heart disease because of the risk of bleeding. The benefits are obvious to people who have already had a heart attack, bypass surgery or blocked arteries that require a stent.
But the best dose is not known, և the study aimed to compare them in real conditions. It was the first experiment funded by the Patient-Centered Research Institute, established in 2010. Patient Protection համաձայն Affordable Care Act to help patients make informed health care decisions.
About 15,000 people have been invited to join by mail, email or phone և registered on a website where they return every three to six months. The network of participating health centers provided participants with medical information from their e-records and insurance claims.
Participants were randomly assigned to take low- or regular-dose aspirin, which they purchased over the counter. “Almost everyone used aspirin before the study, և 85% were already on a low dose, so it was a ‘high-stakes problem from the start’ to force people to take their dose,” says Viran.
About two years later, about 7% of each group died or were hospitalized from a heart attack or stroke. The security results were similar. Less than 1% had severe bleeding that required hospitalization or transfusion.
Nearly 41% of those prescribed higher doses went lower at some point, “said Colin Baygent, a medical scientist at the University of Oxford in the United Kingdom, who wrote in a commentary on the medical issue:” The high rate could “hide the real difference” in terms of safety or effectiveness.
One of the study’s lead authors, Dr. Shueller One ounce of Duke University, said the study still provides valuable guidance. If patients are now taking low-dose aspirin, “staying on that dose instead of changing it is the right choice,” he said. People who work well at 325 milligrams may now want to continue; they should talk to their doctors if they have any concerns.
For new patients, “generally we would recommend starting with a low dose,” said ones ounce.
Virani said people should remember that aspirin is a drug, and although it is sold without a prescription, patients should not make their own decisions about its use.
“Do not change the dose, do not stop talking to anyone,” he warned. “This is especially important for aspirin-like therapy.”
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